Ringing the changes with tetrazole: hydrogen bonding studies

Ringing the changes

Redox-Linked Changes to the Hydrogen-Bonding Network

Ribonucleotide reductase (RNR) catalyzes the conversion of nucleoside diphosphates (NDPs) to 2′-deoxynucleotides, a critical step in DNA replication and repair in all organisms. The class Ia RNRs, which are found in aerobic bacteria and all eukaryotes, are a complex of two subunits: α2 and β2. β2 contains an essential diferric-tyrosyl radical (Y122O•) cofactor required to initiate reduction of ...

Hydrogen bonding

molecules to evolve in the test tube. With the discovery of catalytic RNA, and advances in nucleic acid amplification techniques such as the polymerase chain reaction, it became possible to construct laboratory systems that allow the Darwinian evolution of functional RNA (and later DNA) molecules. This is not evolution based on natural selection, but rather directed evolution based on selection...

JCS in 2010 - ringing in the changes.

DFT and HF Studies: Geometry, Hydrogen Bonding, Vibrational Frequencies and Electronic Properties of Enaminones and Their Complexes with Transition Metals

Enaminones are those structures made up three various functional groups including carbonyl, alkeneand amine groups which arelocated along with each other in a conjugate fashion. These compoundsare of much attention due to special characteristics and numerous applications. In the paper, sixvarious enaminone structures were theoretically optimized and after concluding, were compared withequivalen...